An Emerging Treatment Alternative for Anemia in Chronic Kidney Disease Patients: A Review of Daprodustat
نویسندگان
چکیده
This article reviews an emerging therapeutic agent, which is currently in phase III development for the treatment of anemia secondary to chronic kidney disease, covering promising phase II results, drug characteristics, and the current phase III trials, which, if approved, may significantly impact the management of anemia in this patient population.
منابع مشابه
Effect of pentoxifylline on anemia in patients with chronic kidney disease: an updated systematic review and meta-analysis
Background: Pentoxifylline, a valuable medication with promising clinical characteristics and considerable profile of safety is used in many conditions namely chronic kidney diseases (CKD). However, the decision to prescribe pentoxifylline for anemia in CKD should be based on evidence accrued from randomized controlled trials (RCTs). Yet, substantial heterogeneity exists in studies performed to...
متن کاملپیشبینی مقدار تجویز داروی اریتروپویتین در بیماران همودیالیزی- رویکرد دادهکاوی
Background and purpose: Kidney failure reduces the kidney function and in long term it leads to chronic kidney disease. One of the main complications of this disease is irreversible damage to the kidneys (end-stage kidney disease) and hemodialysis is the main method used to treat advanced kidney failure. The main problem associated with hemodialysis is treating anemia caused by lack of erythrop...
متن کاملNon-albuminuric Diabetic Kidney Disease in Diabetic Patients: A Review
Introduction: The constantly increasing incidence of type 2 diabetes, probably due to obesity and sedentary life, has led to the increased incidence of macro- and microvascular diabetic complications such as nephropathy. Despite the prompt efforts to develop effective treatments for diabetes and slow the progression of its complications, it is still reported as the most common cause of chronic ...
متن کاملALUMINUM TOXICITY: A REVIEW IN RELATION TO CHRONIC RENAL FAILURE PATIENTS M AINTAINED ON REGULAR HEMODIALYSIS
Aluminum is present in very small amounts in living organisms but abundant in the environment. A growing literature links with the biochemistry of aluminum and also with a series of diseases in chronic renal failure patients on treatment with hemodialysis. The initial description of potential aluminum toxicity in renal failure patients relates to description of dialysis encephalopathy syndr...
متن کاملDiscovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia.
Decreased erythropoietin (EPO) production, shortened erythrocyte survival, and other factors reducing the response to EPO contribute to anemia in patients who have a variety of underlying pathologies such as chronic kidney disease. Treatment with recombinant human EPO (rHuEPO) at supraphysiologic concentrations has proven to be efficacious. However, it does not ameliorate the condition in all p...
متن کامل